Unfortunately, neon tetras are occasionally afflicted by the so-called "Neon Tetra Disease" (NTD) or Pleistophora, a sporozoan disease caused by Pleistophora hyphessobryconis. Despite being a well-known condition, it is currently incurable and often fatal to the fish.
The disease cycle begins when microsporidian parasite spores enter the fish after it consumes infected material such as the bodies of a dead fish, or live food such as tubifex, which may serve as intermediate hosts. The disease is most likely to be passed on from newly acquired fish, which have not been quarantined.
Symptoms:
1. Restlessness.
2. Fish begins to lose coloration.
3. As cysts develop, the body may become lumpy.
4. Fish has difficulty swimming.
5. In advanced cases the spine may become curved.
6. Secondary infections such as fin rot and bloating.
Note that there is a so-called "false neon disease", which is bacterial, and shows very similar symptoms. It is impossible for the home aquarist to determine for certain the difference between NTD and false NTD on the basis of visible symptoms alone, without laboratory backup. This disease has also been confused with Columnaris (mouth rot, mouth fungus, 'flex').
To date, there is no known cure: the only 'treatment' is the immediate removal of diseased fish to preserve the remaining fish, but no way to save the diseased fish. The use of a diatom filter, which can reduce the number of free parasites in the water, may help.
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